A driver or a passenger? D421-caspase cleaved tau is associated with aggregated and insoluble tau
نویسندگان
چکیده
منابع مشابه
Caspase Cleaved Tau in Alzheimer’s Disease: A Therapeutic Target Realized
C l i n M e d International Library Citation: Rohn TT (2015) Caspase Cleaved Tau in Alzheimer’s Disease: A Therapeutic Target Realized. Int J Neurol Neurother 1:014. doi.org/10.23937/2378-3001/2/1/1014 Received: January 06, 2015: Accepted: January 09, 2015: Published: January 12, 2015 Copyright: © 2015 Rohn TT. This is an open-access article distributed under the terms of the Creative Commons A...
متن کاملSubmajorization inequalities associated with $tau$-measurable operators
The aim of this note is to study the submajorization inequalities for $tau$-measurable operators in a semi-finite von Neumann algebra on a Hilbert space with a normal faithful semi-finite trace $tau$. The submajorization inequalities generalize some results due to Zhang, Furuichi and Lin, etc..
متن کاملA caspase cleaved form of tau is preferentially degraded through the autophagy pathway.
The microtubule-associated protein tau plays a central role in the pathogenesis of Alzheimer disease (AD) and abnormally accumulates as neurofibrillary tangles; therefore, the pathways by which tau is degraded have been examined extensively. In AD brain tau is abnormally truncated at Asp(421) (tauDeltaC), which increases its fibrillogenic properties and results in compromised neuronal function....
متن کاملAnti-tau antibody reduces insoluble tau and decreases brain atrophy
OBJECTIVE We previously found a strong reduction in tau pathology and insoluble tau in P301S tau transgenic mice following intracerebroventricular infusion of the anti-tau antibody HJ8.5. We sought to determine the effects of HJ8.5 in the same model following peripheral administration. METHODS The primary objective was to determine if HJ8.5 administered at a dose of 50 mg kg(-1) week(-1) by i...
متن کاملRescue from tau-induced neuronal dysfunction produces insoluble tau oligomers
Aggregation of highly phosphorylated tau is a hallmark of Alzheimer's disease and other tauopathies. Nevertheless, animal models demonstrate that tau-mediated dysfunction/toxicity may not require large tau aggregates but instead may be caused by soluble hyper-phosphorylated tau or by small tau oligomers. Challenging this widely held view, we use multiple techniques to show that insoluble tau ol...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Neurodegeneration
سال: 2013
ISSN: 1750-1326
DOI: 10.1186/1750-1326-8-s1-p47